Tools API
Programmatic access to Caelrith’s integrated knowledge graph – clinical trial search, biological associations, drug‑target networks, entity resolution, grant funding analytics, regulatory intelligence, and financial metrics. Each tool has its own daily rate limit defined in your workspace tier.
42 tools across 15 categories · catalog v0.0.0-generated
Clinical Trials4 tools
Trial search, portfolio comparison, trial details.
/api/v1/tools/clinical/portfolio-comparisonPortfolio Comparison
Compare clinical trial portfolios of multiple sponsors for a specific disease. Returns market size, intersection counts, per-sponsor breakdowns, and…
/api/v1/tools/clinical/search-compositeClinical Composite Search
Search clinical trials by disease, drug, target, and sponsor with combination filters. All parameters optional; at least one biological filter recomm…
/api/v1/tools/clinical/trial-detailsTrial Details
Retrieve a single clinical trial's graph-enriched details by NCT ID (exact nct_id match, stored UPPERCASE; NCT ids only - not EU CT numbers). Returns…
/api/v1/tools/clinical/trial-posTrial Probability of Success
Machine-learning Probability of Success (POS) for ONE clinical trial, scored live from the trial's design features (phase, blinding, statistical-anal…
Biology & Targets5 tools
Target-disease associations, drug-target mechanisms, target landscapes.
/api/v1/tools/biology/associationsBiological Associations
Discover target-disease or disease-target associations with confidence scores and evidence counts. Resolves the input entity against targets first, t…
/api/v1/tools/biology/drug-to-targetsDrug to Targets
For a given drug (generic or brand), return all known molecular targets, mechanism of action, and related drug forms (salts, biosimilars). Targets ar…
/api/v1/tools/biology/prioritize-targetsPrioritize Targets
Rank molecular targets for a disease with approved drugs, trial activity, sponsors, and a novelty score. Useful for identifying promising targets for…
/api/v1/tools/biology/target-landscapeTarget Landscape
Explore the competitive landscape for a molecular target: all modulating drugs with approval status, safety warnings, max clinical phase (numeric, co…
/api/v1/tools/biology/target-to-drugsTarget to Drugs
Look up all drugs that modulate a specific biological target (fixed 50-drug cap per call). Returns drug name, phase, approval status, mechanism of ac…
Entity Resolution1 tool
Resolve sponsor / organization names to canonical organization IDs.
Clinical Trial Registry4 tools
Registry-level trial documents: full-text phrase search, topic search, rich field filters, single-trial full records (including resolved PI -> OpenAlex researcher links).
/api/v1/clinical-trialsClinical Trial Registry Search
Paginated search over registry trial DOCUMENTS with full-text phrase search and field filters (all AND-combined). Returns rich per-trial records (tit…
/api/v1/clinical-trials/:trialIdTrial Full Record
Retrieve one complete registry trial document by its registry id, including ALL update_logs, eligibility criteria, officials, contacts, facilities, r…
/api/v1/clinical-trials/sampleTrial Registry Sample
Return up to 5 recently updated trial documents from the registry. Cheap way to inspect the real document shape or to fetch exact OpenAlex topic-name…
/api/v1/clinical-trials/topicsClinical Trials by Topic
Search trials by OpenAlex topic name (exact PHRASE match over openalex_topics[].topic_name; relevance-sorted by default). Accepts every optional filt…
Researchers2 tools
Principal-investigator profiles and their OpenAlex publication records.
/api/v1/researchers/:authorIdResearcher Profile
Profile document for a researcher (principal investigator) resolved to an OpenAlex author. Use trial documents or pi_author_id results from the regis…
/api/v1/researchers/:authorId/worksResearcher Works
Paginated publication list (OpenAlex works) for a researcher already resolved to an OpenAlex author: title, full DOI url, type, publication_date, pub…
Grants & Funding6 tools
NIH and CORDIS funding totals and trends, plus grant registry search and single-grant records.
/api/v1/grantsGrant Registry Search
Paginated full search over NIH RePORTER and EU CORDIS grant RECORDS: full-text search over title/abstract plus indexed filters (source, funding range…
/api/v1/grants/:grantIdGrant Full Record
Retrieve ONE grant's full record by its original identifier (NIH application_id or CORDIS id): title, abstract, funding amount, project start/end dat…
/api/v1/grants/sampleGrant Registry Sample
Return a small fixed sample of recent grants (3 NIH + 2 CORDIS) to preview the real grant document shape. Takes no parameters. Available on all works…
/api/v1/tools/grants/sponsor-fundingSponsor Funding
Retrieve grant funding totals for a sponsor (company, university, or institution), using its resolved entity or raw mention Graph database ID.
/api/v1/tools/grants/topic-fundingTopic Funding
Aggregated grant funding totals for a specific OpenAlex topic, split by NIH and CORDIS sources. Use grants.search for individual grant records under…
/api/v1/tools/grants/topic-funding-historyTopic Funding History
Year-over-year grant funding trends for a specific OpenAlex topic, split by NIH and CORDIS. Returns an array of yearly aggregates sorted ascending.
Regulatory3 tools
Approvals, patents, exclusivities, warnings, regulatory landscapes and dated catalyst events.
/api/v1/tools/regulatory/catalystsRegulatory Catalysts
Dated regulatory catalyst timeline for a sponsor, indication or drug list: FUTURE patent expirations and exclusivity expirations (with human-readable…
/api/v1/tools/regulatory/landscapeRegulatory Landscape
Analyze the regulatory landscape for a sponsor, indication, or specific drugs. Get drugs grouped into biologics, modern small molecules, and commodit…
/api/v1/tools/regulatory/profileRegulatory Profile
Retrieve a complete regulatory profile for a drug, including approvals, patents, exclusivities, safety warnings, and approved indications. Resolves b…
Regulatory Approvals Registry4 tools
Harmonised approval records (FDA Orange Book, FDA Purple Book, EMA): search by trade name, applicant, ingredient, sponsor, drug, disease; one application incl. products/patents/exclusivity on detail; full openFDA labels and label-change history.
/api/v1/regulatoryRegulatory Approvals Search
Paginated search and listing of harmonised regulatory approval RECORDS (FDA Orange Book, FDA Purple Book, EMA). Supports full-text search plus exact,…
/api/v1/regulatory/:idRegulatory Approvals Record
Retrieve ONE harmonised approval by its PUBLIC approval_id (FDA_ORANGE:020610, FDA_PURPLE:BLA125514, EMA:EU/1/20/1528 - copy it verbatim from the app…
/api/v1/regulatory/:id/historyRegulatory Approval Label History
Label-change HISTORY for ONE approval, keyed by the public approval_id: an ascending list of versions, each with effective_time, previous_effective_t…
/api/v1/regulatory/:id/labelRegulatory Approval Label
Full current openFDA label for ONE FDA approval, keyed by the public approval_id (FDA_ORANGE:... / FDA_PURPLE:BLA...). Returns SPL metadata - setid,…
Financials2 tools
Public company cash, burn, runway and financial metrics.
/api/v1/tools/financials/lei-to-tickerLEI to Ticker
Map a Legal Entity Identifier (LEI) to its SEC ticker(s). Returns the LEI entity's name plus data.secEntities - one row per mapped SEC entity ({ticke…
/api/v1/tools/financials/metricsFinancial Metrics
Structured financial metrics for publicly traded companies: cash, liquidity, burn rate, runway, operating cash flow, R&D expense TTM, and a transpare…
Sponsors1 tool
Patents4 tools
Patent publications by company/CPC/date, pre-computed aggregate counts and year-over-year growth, and full patent records with citations and resolved assignees.
/api/v1/patentsPatent Search
Paginated, filterable listing of patent publications using direct indexed filters (company/assignee, CPC classification prefix, publication date rang…
/api/v1/patents/:patentIdPatent Full Record
Retrieve ONE patent's full record by its publication identifier (e.g. WO2021098789A1, EP3823456A1): abstract, inventors, classifications with CPC des…
/api/v1/patents/aggregatePatent Aggregates
Fast pre-computed aggregate patent counts (patent_agg_* tables), grouped by year, CPC code and/or company - group_by accepts a comma-separated subset…
/api/v1/patents/yoy-growthPatent YoY Growth
Year-over-year patent growth by CPC code or company (dimension is required). Returns one row per group with oldCount (year_start), newCount (year_end…
Medicare Drug Spending2 tools
Medicare Part D drug spending (2025): spending, claims, beneficiaries, molecule links and approved indications.
/api/v1/medicare-drugsMedicare Drug Spending Search
Paginated, filterable list of Medicare Part D drugs with 2025 spending data: total spending, claims, beneficiaries, average spending per claim/benefi…
/api/v1/medicare-drugs/:keyMedicare Drug Record
Retrieve ONE Medicare Part D drug's full 2025 spending record by its unique _key (derived from the generic name, e.g. 'aripiprazole'). Returns the fu…